Mixed media and/or photo comics have often been successful. Check out the work of Dave McKean; sometimes he does traditional art (Black Orchid, Arkham Asylum: A Serious Place On Serious Earth), sometimes he does photo manipulation and mixed media (covers to the Sandman series, Mr. Punch) and sometimes really sketchy just-above scribble art (also Mr. Punch, Cages). On the opposite end of the spectrum, check out John J. Muth's M. He took the screenplay from the Fritz Lang film, a bunch of friends, and acted it out with photos. Then he painted it, based on the photos. Beautiful book.
Okay, that's for the real top notch visual artists, let's look at some entertaining comics on the other end of the spectrum. For that we'll delve into the world of webcomics:
http://www.giantitp.com/Comics.html Stick figure D&D story. He's actually a pretty good artist working in the most basic style possible. It's popular (I love it myself) because it's well written, and the style is appealing. But let's face it, us non-artists could probably have done the early strips!
http://www.darthsanddroids.net/ Photo comic based on Star Wars screen caps. The concept is that the characters in the movies are being played by a gaming group (yes, I like RPGs). It's funny and really engaging.
http://www.irregularwebcomic.net/ Same guy, mostly staged Lego stories (he has several going on at once) as well as photo comics of himself.
All of those tend to be gag-a-day, newspaper-style comics (though OOTS has a really well developed through story and gets away with not always being funny). But definitely proof-of-concept that it could definitely work for you! The most important thing that all of these have in common is they developed a style (Mr. Punch shifts styles a lot, but in a consistent manner).
I'm actually in a similar but opposite situation right now. An artist (friend of mine) asked me to write a book for him to illustrate. It's been an interesting collaboration, and getting me to do things that I wouldn't have otherwise. So on that note, if the photo comic doesn't work out the way you want, maybe you could try finding an artist (flyer in the local comic shop and art supply store, look online in comic book forums).
Anyway you do it, definitely do it!